Aapep.bocsci.com - Amino Acids (No review yet)

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The Fluorene methoxy carbonyl (Fmoc) group is an alkali-sensitive protective group, which can be removed in concentrated ammonia or dioxane-methanol/4M NaOH solution and 50% dichloromethane solution of piperidine, ethanolamine, cyclohexylamine, 1, 4-dioxane, pyridinone. Under weak alkali conditions such as sodium carbonate or sodium bicarbonate, Fmoc-Cl or Fmoc-OSu is generally used to introduce the Fmoc protecting group. Compared with Fmoc-Cl, Fmoc-OSu is easier to control the reaction conditions and has fewer side reactions. The Fmoc protecting group is particularly stable under acidic conditions, but is very sensitive to alkaline conditions. Thus, it is usually used together with acid-sensitive protecting groups BOC or CBZ to protect amino acids containing active side chain groups. Fmoc has strong ultraviolet absorption, which can be detected by ultraviolet absorption and brings many conveniences to automatic peptide synthesis of the instrument. And Fmoc is compatible with a wide range of solvents and reagents and used in a variety of supports and activation methods as well as has high mechanical stability. Therefore, Fomc-amino acids are the most commonly used in peptide synthesis today.

Keywords: Amino Acids Resin Pna Monomers Peptides

Category: Science and Research